Open Microsoft Publisher and go to File -> Publish to the web.

First you would have to set your default FTP location. For this purpose click on "Add/Modify FTP Locations" from the Save in drop-down list. In the text box "Name of FTP site", enter your domain name.

In "Log on as" specify your cPanel username and password in the password box.

Finally click on "Add" to save the settings.

To publish your site choose "yourdomain.com" from the Save in drop-list  and navigate to the public_html directory of your web hosting account. Just make sure that the "Save as type" option is set to Web Page, Filtered. Then click on "Save" and your web content will be published.